The short answer to the above question is YES, oral and sublingual HCG is a complete and utter fraud. HCG is only biologically active when injected into the body via a hypodermic needle. This fact apparently does not stop numerous web sites from offering “oral” or “sublingual” forms of HCG for sale in order to avoid the need for injections. Advertisements promoting these forms of HCG do not contain actual HCG since HCG must be dispensed by prescription only and must to be given by injection to be effective.
Claims that HCG can be absorbed in the oral mucosa are nonsense. To date, science hasn’t been able to produce a way to deliver the intact HCG hormone into the blood stream in any way except by injection, just as insulin has to be given by injection to be effective. HCG is over 5 times larger than insulin and it is not possible for that size of protein to be absorbed through a person’s mucus membranes. If it is taken orally the HCG protein is digested by enzymes that break it up into amino acids and it is no longer HCG. The 244 amino acids in this large, fragile polypeptide hormone (HCG) are in exact sequence with a specific 3-dimensional shape, which fits cell receptors like a key in a lock. Even if the chemical formula remains the same, a change in shape blocks HCG activity. Once dissolved in a solution, the cross-linkages maintaining the shape break quite easily and can become unstable.
The fact is all of the published benefits of using HCG for rapid weight loss are based on injected HCG. None of its prized benefits are seen with oral or sublingual forms. One of the major effects of receiving HCG by injection is that the person’s appetite is severely suppressed. When oral or sublingual forms of HCG are given, an additional oral appetite suppressant must also be given, thus providing additional evidence that HCG does not actually get into the individual’s circulation with these methods of administration.
There are no published reports that have been able to demonstrate a measurable amount of HCG in a person’s blood when given in either oral or sublingual forms. The one report that is cited by most web sites as providing proof actually states “On treatment days 0, 15, and 30 we have tested all volunteers, screening for the presence of plasmatic hCG. Concentrations were undetectable in all cases (data not shown).”* The study was poorly designed as well because it did not include proper controls. There was no group of people tested that were given HCG via injection, the only proven way of getting the benefits of using HCG for rapid weight loss. Furthermore, the study was not published in a peer reviewed medical journal. Instead, it was published on the primary author’s website.
Claims that oral or sublingual HCG are as effective as when HCG is given by injection are marketing attempts intended to deceive scientifically unsophisticated consumers. Bottom line, the only effective and safe way to receive the benefits of HCG for rapid weight loss is via injection with a prescription under the supervision of a licensed physician.
*Utility of an oral presentation of hCG (human Choriogonadotropin) for the management of obesity. A double-blind study. By D. Belluscio, L. Ripamonte and M. Wolansky. Published on D. Belluscio’s website www.hcgobesity.org.
David L. Walters, DO, PhD
511 W. 29th St., Ste. C
Pueblo, CO 81008
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